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  • Brain-dead man receives pig kidney. Transplant could become a game-changer

Brain-dead man receives pig kidney. Transplant could become a game-changer

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In a medical breakthrough, NYU Langone surgeons successfully transplanted a pig kidney into a brain-dead man who has now survived on the organ for over a month.

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“This represents the longest period that a gene-edited pig kidney has functioned in a human, and the latest step toward the advent of an alternate, sustainable supply of organs for transplant,” according to an NYU Langone news release.

The surgical staff also gave a special thanks to Mary Miller Duffy, the sister of the brain-dead man, Maurice Miller, who allowed her brother’s body to be used for the innovative procedure.

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“I want to begin by acknowledging how grateful we all are to Mary, who’s sitting next to me,” said Dr. Robert Montgomery at a news presentation attended by The Post.

“She, at a time of profound grief, found a way to help her brother to realize his desire to give a gift to humanity at the time of his death,” added Montgomery, lead surgeon and chair of the NYU Langone Department of Surgery.

Research on the first-of-its-kind operation, which took place July 14, will continue into mid-September, as doctors monitor how long the animal’s kidney will function properly inside a human body beyond 32 days.

The pig kidney had only “one genetic modification and [is] without experimental medications or devices,” according to Montgomery.

In xenotransplants, the medical term for a cross-species organ transplant, Montgomery and his team had to create a unique solution for the patient’s body to avoid “hyperacute rejection” of the animal’s organ once it connected to the 57-year-old man’s circulatory system.

This was done by “knocking out” the alpha-gal gene that doctors altered to prevent a rejection in the man.

Additionally, the pig’s thymus gland — which communicates with its immune system — “was embedded underneath the outer layer of the kidney to stave off novel, delayed immune responses.

“The combination of modifications has been shown to prevent rejection of the organ while preserving kidney function,” according to NYU.

This potentially game-changing surgery, part of a larger study on the subject, could someday prove an efficient treatment for the more than 103,000 people in need of organ transplants across the U.S.

“There are simply not enough organs available for everyone who needs one,” said Montgomery, who himself had a heart transplant five years ago. “Too many people are dying because of the lack of available organs, and I strongly believe xenotransplantation is a viable way to change that.”

Montgomery’s latest success not only reduced the amount of genetic modifications needed from ten to one, but could lead to the surgery becoming a viable option for people in need during the years to come.

“We’ve now gathered more evidence to show that, at least in kidneys, just eliminating the gene that triggers a hyperacute rejection may be enough along with clinically approved immunosuppressive drugs to successfully manage the transplant in a human for optimal performance — potentially in the long-term,” Montgomery said.

“We think using a pig already deemed safe by the FDA, in combination with what we have found in our xenotransplantation research so far, gets us closer to the clinical trial phase,” Montgomery added.

“We know this has the potential to save thousands of lives, but we want to ensure the utmost safety and care as we move forward.”

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One response to “Brain-dead man receives pig kidney. Transplant could become a game-changer”

REQUEST FOR EXPRESSIONS OF INTEREST

(CONSULTING SERVICES – INDIVIDUAL SELECTION)

 

OECS MSME Guarantee Facility Project

Loan No.: IDA-62670, IDA-62660, IDA-62640, IBRD-88830, IDA-62650

Assignment Title: Senior Operating Officer (SOO)

Reference No. KN-ECPCGC-207852-CS-INDV

 

The Governments of Antigua and Barbuda, Commonwealth of Dominica, Grenada, St. Lucia and St. Vincent and the Grenadines have received financing in the amount of US$10 million equivalent from the World Bank towards the cost of establishing a partial credit guarantee scheme, and they intend to apply part of the proceeds to payments for goods, and consulting services to be procured under this project. 

The consultant will serve as the “Senior Operating Officer (SOO)” for the ECPCGC and should possess extensive knowledge of MSME lending with some direct experience lending to Micro, small and medium-sized businesses, knowledge of the internal control processes necessary for a lending operation and the ability to design and implement risk mitigation procedures. The ideal candidate should possess an Undergraduate Degree from a reputable college or university, preferably in Business, Accounting, Banking or related field, with a minimum of 5 years’ experience in lending, inclusive of MSME lending. The initial employment period will be for two years on a contractual basis. Renewal of the contract will be subject to a performance evaluation at the end of the contractual period. The assignment is expected to begin on September 30th, 2021.  The consultant will report directly to the Chief Executive Officer of the ECPCGC.

The detailed Terms of Reference (TOR) for the assignment can be viewed by following the attached link below. 

 

https://bit.ly/3iVannm

 

The Eastern Caribbean Partial Credit Guarantee Corporation (ECPCGC) now invites eligible “Consultants” to indicate their interest in providing the Services. Interested Consultants should provide information demonstrating that they have:

  • An Undergraduate Degree from a reputable college or university, preferably in Business, Finance, Banking or related field; and
  • Minimum of 5 years’ experience in MSME lending. Applicants should also have:
  • The ability to design and implement risk management procedures 
  • Extensive knowledge of MSME lending with some direct experience lending to small and medium-sized businesses
  • Extensive knowledge of MSME banking operations
  • Knowledge of the internal controls necessary for a lending operation and the ability to design and implement risk management procedures
  • Experience developing and presenting information in public, including responding to questions in real-time
  • Experience lending to MSMEs located in the ECCU
  • Knowledge of marketing and communicating with the MSME sector
  • Ability to draft procedures to be used in a lending operation
  • Familiarity with the mechanics of a loan guarantee program
  • Exceptional written, oral, interpersonal, and presentation skills, and
  • Proficiency in the use of Microsoft Office suite.

The attention of interested Individual Consultants is drawn to Section III, Paragraphs 3.14, 3.16, and 3.17 of the World Bank’s Procurement Regulations for IPF Borrowers July 2016, [revised November 2017] (“Procurement Regulations”), setting forth the World Bank’s policy on conflict of interest. A Consultant will be selected in accordance with the Approved Selection Method for Individual Consultants set out in the clause 7.34 of the World Bank Procurement Regulations for IPF Borrowers. 

 

Further information can be obtained at the address below during office hours 0800 to 1700 hours:

Eastern Caribbean Partial Credit Guarantee Corporation

Brid Rock, Basseterre,

St. Kitts.

Expressions of interest must be delivered in a written form by e-mail by August 11th, 2021, to [email protected]

 

For further information, please contact:

Carmen Gomez-Trigg                                                            Bernard Thomas

Chief Executive Officer                                                          Chief Financial Officer

Tel: 868-620-8144                                                                  Tel: 869-765-2385

Email: [email protected]                                          [email protected]